Resistance of Natural Killer T Cell–Deficient Mice to Systemic Shwartzman Reaction
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چکیده
منابع مشابه
Resistance of Natural Killer T Cell–Deficient Mice to Systemic Shwartzman Reaction
The generalized Shwartzman reaction in mice which had been primed and challenged with lipopolysaccharide (LPS) depends on interleukin (IL)-12-induced interferon (IFN)-gamma production at the priming stage. We examined the involvement in the priming mechanism of the unique population of Valpha14 natural killer T (NKT) cells because they promptly produce IFN-gamma after IL-12 stimulation. We repo...
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Lipid overload and adipocyte dysfunction are key to the development of insulin resistance and can be induced by a high-fat diet. CD1d-restricted invariant natural killer T (iNKT) cells have been proposed as mediators between lipid overload and insulin resistance, but recent studies found decreased iNKT cell numbers and marginal effects of iNKT cell depletion on insulin resistance under high-fat...
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The generalized Shwartzman reaction can be produced in pregnant rats by the simple addition of oxidized off to the diet. In spite of the absence of any pathologic evidence of a bacterial infection in 90 per cent of the animals (1), the possibility remains that bacterial products from some endogenous source may be responsible for the development of the reaction under these experimental condition...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2000
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.192.11.1645